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New Orleans Saints vs. Arizona Cardinals Prediction NFL in American Football

Match Analysis: New Orleans Saints vs Arizona Cardinals – Prediction

Match Details

  • Date: 2025-09-07
  • Time: 5:00 PM UTC
  • Location: Caesars Superdome, New Orleans

Game Overview

The Arizona Cardinals enter as strong road favorites at -6.5 against the New Orleans Saints, who are undergoing a rebuild with a new head coach and a struggling offense. The Cardinals have a more balanced roster and optimism under head coach Jonathan Gannon. This Week 1 matchup projects Arizona to control the game pace and cover the spread.

Key Factors to Consider

  • Arizona has a 2-1 preseason record and improved offensive capabilities, while New Orleans finished 0-2-1 in preseason showing offensive struggles and defensive vulnerabilities.
  • Recent H2H data favors Arizona as the superior team given their roster stability and offensive punch, while New Orleans has faced challenges maintaining consistent results.
  • No major injury reports drastically change the outlook; however, New Orleans' key offensive players have not shown breakout performances in preseason.
  • Arizona benefits from momentum entering Week 1 with renewed expectations, while New Orleans faces pressure to restart under new coaching staff and quarterback Spencer Rattler.
  • Arizona is motivated to start the season strong as a contender, whereas New Orleans appears to be in a rebuilding phase, lowering their motivation for a Week 1 upset.

Odds and Predictions

Category Odds Prediction Confidence
Moneyline Arizona Cardinals -298, New Orleans Saints +240 Arizona Cardinals ★★★★☆ 78%
Spread Arizona Cardinals -6.5 -110, New Orleans Saints +6.5 -110 Arizona Cardinals -6.5 ★★★★☆ 74%
Over/under Over 43.5 -108, Under 43.5 -112 Under 43.5 ★★★☆☆ 69%

Top EV Betting Odds

Discover the best value bets based on our EV analysis.

Market EV Pick
Moneyline Arizona Cardinals -3%
Spread N/A
Over/Under Under 43.5 17%

🔥 Best Value Pick: Under 43.5 at 17% EV | Suggested Bet Size: 19.4% (Kelly Criterion)

Predicted Outcome

Arizona Cardinals to win moneyline and cover the spread; game total under 43.5 points.

Predicted Score: Arizona Cardinals 24 – New Orleans Saints 14


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Top EV Parlay for American Football – September 7, 2025 Daily Parlay

Top EV Parlay for American Football – September 7, 2025

Game Pick Odds EV
New Orleans Saints vs. Arizona Cardinals Prediction Under 43.5 -112 17%
Jacksonville Jaguars vs. Carolina Panthers Prediction Under 46.5 -105 17%
Cleveland Browns vs. Cincinnati Bengals Prediction Under 48.5 -112 14%

Combined Odds: +600 |
Wager: $20 —
Potential Payout: $139.9

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3 Pick Parlay for American Football – September 7, 2025 Daily Parlay

3 Pick Daily Parlay

Game Pick Odds (American) Confidence
Jacksonville Jaguars vs. Carolina Panthers Prediction Jacksonville Jaguars Win -185 ★★★★☆ 78% (78%)
New Orleans Saints vs. Arizona Cardinals Prediction Arizona Cardinals Win -298 ★★★★☆ 78% (78%)
Washington Commanders vs. New York Giants Prediction Washington Commanders Win -270 ★★★★☆ 76% (76%)

Parlay Odds Calculation

Combined American Odds: +182

Wager: $20 — Potential Payout: $56.39

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