Match Analysis: Arizona Cardinals vs San Francisco 49ers – Prediction

Match Details

• Date: 2025-11-16
• Time: 9:05 PM UTC
• Location: State Farm Stadium, Arizona

Game Overview

The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) in a crucial NFC West clash. The 49ers seek to maintain momentum after recent recovery from losses, while the Cardinals aim to leverage home advantage despite a poor season record.

Key Factors to Consider

• 49ers are 6-4 overall and have covered the spread in their last four games following a loss. Cardinals are 3-6, struggling against winning teams and have a poor 1-3 home record this season.
• 49ers have dominated recent matchups, winning 4 of last 5 vs Cardinals. Cardinals have found some success as underdogs, covering in 9 of last 10 games after a loss, but have lost 8 straight to teams with winning records.
• No major injuries reported on either side that significantly alter starting lineups or depth charts as of current data.
• Game played at Cardinals' home stadium where 49ers have historically struggled on Sundays (lost 9 of last 10), but recent form for 49ers on road is positive.
• 49ers motivated to sustain playoff push and rebound after losses; Cardinals appear resigned to missing playoffs, which may reduce competitive edge.

Odds and Predictions

Predicted Outcome

San Francisco 49ers moneyline win

Predicted Score: San Francisco 49ers 27, Arizona Cardinals 20

Match Analysis: San Francisco 49ers vs Los Angeles Rams – Prediction

Match Details

• Date: 2025-11-09
• Time: 9:25 PM UTC
• Location: Levi's Stadium, Santa Clara, California

Game Overview

This NFC West clash features the 6-2 Los Angeles Rams visiting the 6-3 San Francisco 49ers. Both teams have strong recent performances, with the Rams coming off a dominant 34-10 win over New Orleans and the 49ers narrowly beating the Giants 34-24 on the road. The Rams are favored -4.5 on the spread with moneyline odds at -225, while the 49ers are +185 underdogs at home. The over/under is set at 49.5 points.

Key Factors to Consider

• Rams have a 6-2 record, strong defensive showings, and average controlling the game on both sides. 49ers are 6-3 with efficient offense, particularly in the red zone, showing resilience at home.
• Rams won the first meeting in a close contest, 26-23 in overtime. Revenge is a key factor for the Rams.
• Rams have multiple key players questionable (WR Jordan Whittington, DT Kalia Davis, DE Keion White, and others). The 49ers have fewer reported impactful injuries.
• Game played at Levi's Stadium in Santa Clara favors the 49ers slightly due to home crowd and weather conditions. Rams show strong motivation to avenge an earlier OT loss.
• Rams motivated by revenge after close earlier loss. 49ers incentivized to maintain home edge and division standing.

Odds and Predictions

Predicted Outcome

Moneyline: Los Angeles Rams to win; Spread: Los Angeles Rams -4.5; Over/Under: Over 49.5 points

Predicted Score: Los Angeles Rams 27 – 21 San Francisco 49ers

Match Analysis: New York Giants vs San Francisco 49ers – Prediction

Match Details

• Date: 2025-11-02
• Time: 6:00 PM UTC
• Location: MetLife Stadium

Game Overview

The San Francisco 49ers (5-3) visit the New York Giants (2-6) for an NFL Week 9 cross-conference matchup. The 49ers are favored and looking to rebound from a recent loss, while the Giants struggle with a poor record and key injuries. The game likely hinges on which team controls tempo and limits mistakes.

Key Factors to Consider

• San Francisco has a stronger record (5-3) and better offensive rankings, especially in passing yards (2nd in league). New York is struggling at 2-6 with inconsistency and key injuries reducing offensive potency.
• No significant recent data available on direct matchups; 49ers hold a general advantage given form and roster strength.
• Giants have a critical injury with rookie RB Cam Skattebo out for the season. 49ers are missing key WRs including Brandon Aiyuk and QB Brock Purdy, which may impact passing but have depth with McCaffrey and Kittle healthy.
• The game is at Giants’ home in MetLife Stadium. Giants have struggled at home this season. Weather conditions not reported as a factor.
• 49ers remain in playoff contention in a competitive NFC West, motivated to stabilize after a recent loss. Giants appear to be out of realistic playoff contention and may be focusing on future development.

Odds and Predictions

Predicted Outcome

San Francisco 49ers to win and cover the 2.5-point spread; total points under 48.5

Predicted Score: 49ers 25, Giants 21

Match Analysis: Houston Texans vs San Francisco 49ers – Prediction

Match Details

• Date: 2025-10-26
• Time: 5:00 PM UTC
• Location: NRG Stadium, Houston, TX

Game Overview

Two playoff contenders clash as the San Francisco 49ers visit the Houston Texans in a matchup with potential postseason implications. Both teams have shown offensive firepower, but Houston’s stingy defense could be the difference against a San Francisco squad that has alternated wins and losses recently.

Key Factors to Consider

• The 49ers (5-2) have struggled for consistency, alternating wins and losses over their last five games, but are tied for first in the NFC West. Their run game (95.3 YPG) has lagged behind their passing (271.3 YPG), while the defense allows 19.7 PPG. Houston (2-4) has won two of their last three, dominating the Ravens and Titans, with defense leading the league (14.7 PPG allowed) [1]. CJ Stroud is playing efficiently, and their running game (106.2 YPG) is solid. The Texans look to be clicking at the right time.
• No direct recent H2H data available, but Texans are playing with confidence after big wins, while the 49ers’ record is boosted by mostly close wins.
• No major injury news reported—assume both teams are near full strength [1].
• Home field advantage for Houston; possible defensive slugfest as both teams have shown stronger defense and inconsistent scoring output.
• The 49ers want to stay atop the NFC West, while Houston seeks a third straight win to climb in the AFC South.

Odds and Predictions

Predicted Outcome

Houston’s hot streak, elite defense, and home field will edge out a 49ers team that has yet to put together a consistent stretch. Expect a low-scoring game decided by field position and turnovers.

Predicted Score: Houston Texans 23, San Francisco 49ers 20

Match Analysis: San Francisco 49ers vs Atlanta Falcons – Prediction

Match Details

• Date: 2025-10-19
• Time: 12:20 AM UTC
• Location: Levi's Stadium

Game Overview

The San Francisco 49ers host the Atlanta Falcons in a crucial Week 7 matchup.

Key Factors to Consider

• The 49ers are currently 4-2, while the Falcons are 3-2. The 49ers have a strong home record, but they're only 1-1 at home so far. The Falcons have been inconsistent on the road.
• San Francisco leads the all-time series, 48-33-1. However, the Falcons won their last meeting in 2022.
• Injury reports are not provided in the available data, but monitoring them could impact the game's outcome.
• The weather in Santa Clara is generally mild, which shouldn't significantly affect either team's performance.
• Both teams are motivated to win, with the 49ers looking to improve their home record and the Falcons seeking to bolster their playoff chances.

Odds and Predictions

Predicted Outcome

The 49ers are favored and have a slight edge due to their overall form and home advantage, but the Falcons have shown resilience.

Predicted Score: 23-20, San Francisco 49ers

Match Analysis: Tampa Bay Buccaneers vs San Francisco 49ers – Prediction

Match Details

• Date: 2025-10-12
• Time: 8:26 PM UTC
• Location: Raymond James Stadium

Game Overview

A clash between NFC contenders, both entering 4-1 but with subtle differences in strength of victory. Live bookmaker odds suggest Tampa Bay is a slight home favorite, but the 49ers have been resilient on the road (3-0 away). The game features two of the NFL’s most balanced teams in 2025, with both offenses and defenses ranking in the upper tier.

Key Factors to Consider

• Both teams are 4-1, but Tampa Bay's wins have been more convincing in terms of margin and quality of opponent. 49ers have won three straight, all on the road, but two by less than a field goal. Bucs have covered the spread in 3/5 games, but failed the one time they were favored by 3+; 49ers covered both as underdogs this season[2].
• Recent H2H data is limited for 2025; historical trends show both teams as competitive against NFC counterparts, but no overwhelming edge for either side.
• No major injuries reported for either team that would significantly impact the current spread or total. (Note: Check for late-breaking updates.)
• No significant weather or venue concerns expected for Tampa Bay’s indoor/outdoor stadium. Both teams travel regularly and are accustomed to east coast games.
• Both teams are jockeying for NFC playoff seeding and division leads. Motivation equally high for both, with neither squad likely to overlook this game.

Odds and Predictions

Predicted Outcome

A tight game with both teams playing disciplined football. Tampa’s slight home edge and recent strength of schedule could prove decisive in a field-goal-type contest, but San Francisco’s road resilience and value on the spread make them the sharper play. The under is the most confident pick overall, given both defenses and recent scoring trends.

Predicted Score: Tampa Bay Buccaneers 24 – San Francisco 49ers 23[2]

3 Pick Daily Parlay

Parlay Odds Calculation

Combined American Odds: +597

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Match Analysis: Los Angeles Rams vs San Francisco 49ers – Prediction

Match Details

• Date: 2025-10-02
• Time: 12:16 AM UTC
• Location: SoFi Stadium

Game Overview

The Los Angeles Rams and San Francisco 49ers face off in a crucial NFC West matchup. Both teams are 3-1, indicating strong momentum and competitive prowess. This game has significant divisional implications.

Key Factors to Consider

• Both teams have shown strong performance, but the Rams have slightly better recent form ATS. The 49ers struggle on the road, going 0-5 ATS in their last away games.
• Previous matchups have been competitive, but recent trends suggest the Rams have an edge.
• Current injury reports are not detailed, but both teams have shown resilience despite past injuries.
• The game is at SoFi Stadium, which could slightly favor the Rams due to home advantage.
• Both teams are highly motivated due to the divisional stakes.

Odds and Predictions

Predicted Outcome

Los Angeles Rams to win, 49ers to cover the spread, and under on the total.

Predicted Score: Rams 24, 49ers 20

Match Analysis: San Francisco 49ers vs Jacksonville Jaguars – Prediction

Match Details

• Date: 2025-09-28
• Time: 8:06 PM UTC
• Location: Levi's Stadium, San Francisco

Game Overview

The San Francisco 49ers enter the game undefeated at 3-0, hosting the Jacksonville Jaguars who are 2-1. The 49ers have shown strong defensive prowess and offensive consistency, while the Jaguars rely on opportunistic big plays but have shown offensive inconsistency.

Key Factors to Consider

• 49ers lead the NFL with a 3-0 record, featuring a stout defense allowing 17 points per game and efficient offense with Mac Jones stepping up recently. Jaguars are 2-1 with inconsistent offensive execution though their defense limits opponents to 292 yards per game.
• Recent matchups favor the 49ers, with their defense making key stops and forcing turnovers against the Jaguars' less consistent offense.
• 49ers adapt well despite injuries to Brock Purdy, with Mac Jones healthy and performing well. Jaguars have no major reported injuries affecting key players.
• Home field advantage and a sellout crowd at Levi’s Stadium support the 49ers. Travel and time zone differences slightly disadvantage the Jaguars.
• 49ers aim to maintain their undefeated streak and home dominance. Jaguars seek redemption and to prove their growth under coach Liam Coen.

Odds and Predictions

Predicted Outcome

San Francisco 49ers to win straight up, cover the -3.5 spread, and the total scoring to go under 46.5 points.

Predicted Score: 49ers 23 – Jaguars 17

Match Analysis: San Francisco 49ers vs Arizona Cardinals – Prediction

Match Details

• Date: 2025-09-21
• Time: 8:26 PM UTC
• Location: Levi's Stadium, Santa Clara, California

Game Overview

A tightly contested NFC West divisional matchup between two undefeated teams with strong defenses and capable offenses. The 49ers enter favored at home by a narrow margin versus the Cardinals who have recent success against them in head-to-head matchups.

Key Factors to Consider

• Both teams are 2-0 with solid recent wins; 49ers show balanced offense with 344 yards last game and solid defense; Cardinals have won last two meetings convincingly and boast a strong running and passing attack.
• Cardinals have won last two meetings including a 47-24 road win; overall H2H in last 10 is balanced at 5-5.
• No major injury reports impacting key starters disclosed prior to game, both teams expected near full strength.
• Game played at Levi's Stadium benefits the 49ers' home advantage; weather not expected to be a factor.
• Both teams motivated to maintain perfect records early in season and gain divisional edge; recent psychological edge to Cardinals from last two wins.

Odds and Predictions

Predicted Outcome

Arizona Cardinals moneyline upset win given momentum and favorable head-to-head, with moderate confidence to back this undervalued line; expect moderately high scoring game.

Predicted Score: Cardinals 27 – 49ers 24