Match Analysis: Indianapolis Colts vs Arizona Cardinals – Prediction
Match Details
- Date: 2025-10-12
- Time: 5:01 PM UTC
- Location: Lucas Oil Stadium, Indianapolis, IN
Game Overview
The Indianapolis Colts (4-1) host the Arizona Cardinals (2-3) in Week 6 of the 2025 NFL season. The Colts lead the AFC South and have been performing strongly at home (3-0), while the Cardinals have struggled on the road (1-1) with a losing overall record. Both teams have dynamic coaching matchups, with Jonathan Gannon and Shane Steichen facing off for the first time as opposing head coaches.
Key Factors to Consider
- Indianapolis Colts have started the season strong with a 4-1 record, leading the AFC South, scoring 163 points while conceding 89. They are undefeated at home (3-0). The Cardinals hold a 2-3 record, scoring 103 points and conceding 96, showing inconsistencies especially in away games.
- No recent direct matchup data for the 2025 season was found. Historical matchups generally favor the Colts, especially at home, but specific recent head-to-head analysis is limited.
- Current search results do not provide detailed injury reports for either team ahead of this matchday. Key player availability could impact the outcome but is unknown based on available data.
- Playing at Lucas Oil Stadium gives the Colts home advantage. Weather conditions and travel burdens favor the Colts who are well-rested after a recent home win. The Cardinals have a tough schedule and are recovering from recent losses.
- The Colts are motivated to maintain their lead in the AFC South and capitalize on home advantage. The Cardinals are coming off a losing stretch and need a road win to improve playoff chances and team morale.
Odds and Predictions
| Category | Odds | Prediction | Confidence |
|---|---|---|---|
| Moneyline | Arizona Cardinals: 300, Indianapolis Colts: -380 | Indianapolis Colts | โ โ โ โ โ 85% |
| Spread | Arizona Cardinals: 7.5 -108, Indianapolis Colts: -7.5 -112 | Indianapolis Colts -7.5 | โ โ โ โ โ 78% |
| Over/under | Over: 46.5 -110, Under: 46.5 -110 | Under 46.5 | โ โ โ โโ 65% |
Top EV Betting Odds
Discover the best value bets based on our EV analysis.
| Market | EV Pick |
|---|---|
| Moneyline | Indianapolis Colts -0% |
| Spread | N/A |
| Over/Under | Under 46.5 11% |
๐ฅ Best Value Pick: Under 46.5 at 11% EV | Suggested Bet Size: 11.8% (Kelly Criterion)
Predicted Outcome
Indianapolis Colts are favored to win this game decisively due to better season form, home advantage, and stronger statistical performance on both sides of the ball.
Predicted Score: Indianapolis Colts 27, Arizona Cardinals 16