The San Francisco 49ers (1-0) visit the New Orleans Saints (0-1) in Week 2, with the 49ers favored as they seek to start their season 2-0 on the road, a trend linked to past deep playoff runs.
Key Factors to Consider
San Francisco started 1-0 with a win over Seattle, showing strong on-road performance historically vs. Saints (4-8 SU but with recent dominant tendencies). New Orleans is 0-1 with a rebuilding team under rookie coach Kellen Moore.
Historically, 49ers are 4-8 SU on road vs. Saints but have shown dominance in recent seasons when starting strong. ATS records favor the Saints recently, but line movement favors 49ers.
49ers likely without starting QB Brock Purdy due to toe injury; backup Mac Jones expected from solid camp performances. Saints' QBs and key starters largely healthy but unproven early in season.
The game takes place in the Saints' home dome, but 49ers' strong road starts correlate with playoff success, adding psychological motivation. Weather not a factor (domed stadium).
49ers have strong motivation to maintain early momentum and prove depth despite Purdy's injury, while Saints aim to avoid an 0-2 start amid rebuild.
Odds and Predictions
Category
Odds
Prediction
Confidence
Moneyline
New Orleans +142, San Francisco -170
San Francisco
β β β β β 78%
Spread
New Orleans +3 -105, San Francisco -3 -115
San Francisco -3
β β β β β 72%
Over/under
Over 40.5 -112, Under 40.5 -108
Under 40.5
β β β ββ 65%
Top EV Betting Odds
Discover the best value bets based on our EV analysis.
Market
EV Pick
Moneyline
San Francisco 49ers -8%
Spread
N/A
Over/Under
Under 40.5 25%
π₯ Best Value Pick: Under 40.5 at 25% EV | Suggested Bet Size: 27.2% (Kelly Criterion)
Predicted Outcome
San Francisco 49ers to win straight up and cover the -3 spread with a final score under 40.5 points.
Predicted Score: San Francisco 23 – New Orleans 17
The Arizona Cardinals enter as strong road favorites at -6.5 against the New Orleans Saints, who are undergoing a rebuild with a new head coach and a struggling offense. The Cardinals have a more balanced roster and optimism under head coach Jonathan Gannon. This Week 1 matchup projects Arizona to control the game pace and cover the spread.
Key Factors to Consider
Arizona has a 2-1 preseason record and improved offensive capabilities, while New Orleans finished 0-2-1 in preseason showing offensive struggles and defensive vulnerabilities.
Recent H2H data favors Arizona as the superior team given their roster stability and offensive punch, while New Orleans has faced challenges maintaining consistent results.
No major injury reports drastically change the outlook; however, New Orleans' key offensive players have not shown breakout performances in preseason.
Arizona benefits from momentum entering Week 1 with renewed expectations, while New Orleans faces pressure to restart under new coaching staff and quarterback Spencer Rattler.
Arizona is motivated to start the season strong as a contender, whereas New Orleans appears to be in a rebuilding phase, lowering their motivation for a Week 1 upset.
Odds and Predictions
Category
Odds
Prediction
Confidence
Moneyline
Arizona Cardinals -298, New Orleans Saints +240
Arizona Cardinals
β β β β β 78%
Spread
Arizona Cardinals -6.5 -110, New Orleans Saints +6.5 -110
Arizona Cardinals -6.5
β β β β β 74%
Over/under
Over 43.5 -108, Under 43.5 -112
Under 43.5
β β β ββ 69%
Top EV Betting Odds
Discover the best value bets based on our EV analysis.
Market
EV Pick
Moneyline
Arizona Cardinals -3%
Spread
N/A
Over/Under
Under 43.5 17%
π₯ Best Value Pick: Under 43.5 at 17% EV | Suggested Bet Size: 19.4% (Kelly Criterion)
Predicted Outcome
Arizona Cardinals to win moneyline and cover the spread; game total under 43.5 points.
Predicted Score: Arizona Cardinals 24 – New Orleans Saints 14