Top EV Parlay for American Football – September 21, 2025

Game	Pick	Odds	EV
San Francisco 49ers vs. Arizona Cardinals Prediction	Arizona Cardinals	110	22%
Minnesota Vikings vs. Cincinnati Bengals Prediction	Under 41.5	-105	21%
New York Giants vs. Kansas City Chiefs Prediction	Under 45.5	-115	16%

Combined Odds: +667 |
Wager: $20 —
Potential Payout: $153.3

Match Analysis: New Orleans Saints vs San Francisco 49ers – Prediction

Match Details

• Date: 2025-09-14
• Time: 5:01 PM UTC
• Location: Caesars Superdome

Game Overview

The San Francisco 49ers (1-0) visit the New Orleans Saints (0-1) in Week 2, with the 49ers favored as they seek to start their season 2-0 on the road, a trend linked to past deep playoff runs.

Key Factors to Consider

• San Francisco started 1-0 with a win over Seattle, showing strong on-road performance historically vs. Saints (4-8 SU but with recent dominant tendencies). New Orleans is 0-1 with a rebuilding team under rookie coach Kellen Moore.
• Historically, 49ers are 4-8 SU on road vs. Saints but have shown dominance in recent seasons when starting strong. ATS records favor the Saints recently, but line movement favors 49ers.
• 49ers likely without starting QB Brock Purdy due to toe injury; backup Mac Jones expected from solid camp performances. Saints' QBs and key starters largely healthy but unproven early in season.
• The game takes place in the Saints' home dome, but 49ers' strong road starts correlate with playoff success, adding psychological motivation. Weather not a factor (domed stadium).
• 49ers have strong motivation to maintain early momentum and prove depth despite Purdy's injury, while Saints aim to avoid an 0-2 start amid rebuild.

Odds and Predictions

Category	Odds	Prediction	Confidence
Moneyline	New Orleans +142, San Francisco -170	San Francisco	★★★★☆ 78%
Spread	New Orleans +3 -105, San Francisco -3 -115	San Francisco -3	★★★★☆ 72%
Over/under	Over 40.5 -112, Under 40.5 -108	Under 40.5	★★★☆☆ 65%

Top EV Betting Odds

Discover the best value bets based on our EV analysis.

Market	EV Pick
Moneyline	San Francisco 49ers -8%
Spread	N/A
Over/Under	Under 40.5 25%

🔥 Best Value Pick: Under 40.5 at 25% EV | Suggested Bet Size: 27.2% (Kelly Criterion)

Predicted Outcome

San Francisco 49ers to win straight up and cover the -3 spread with a final score under 40.5 points.

Predicted Score: San Francisco 23 – New Orleans 17

Match Analysis: Seattle Seahawks vs San Francisco 49ers – Prediction

Match Details

• Date: 2025-09-07
• Time: 8:05 PM UTC
• Location: Lumen Field

Game Overview

The Seattle Seahawks host the San Francisco 49ers in an NFC West opener with both teams coming off offseason challenges and injury concerns, especially on the 49ers' offense. Expect a competitive, close game with slightly subdued scoring due to key offensive injuries.

Key Factors to Consider

• San Francisco is historically strong in September with a 5-2 SU record in the last 7 Septembers but faces early-season injury issues; Seattle has struggled ATS recently (1-4 in last 5) but shows promise at home and a resilient defense.
• Recent matchups have been close, with 49ers generally favored but margins often tight; early September clashes show competitive balance.
• 49ers’ star RB Christian McCaffrey is limited with a calf injury and possibly not fully fit; WR Brandon Aiyuk likely out; Jauan Jennings injured; Seattle's key injuries less pronounced but QB Sam Darnold status stable yet not elite.
• Game in Seattle at Lumen Field favors Seahawks with home crowd; weather typically mild in September; line moved slightly due to McCaffrey injury.
• Both teams highly motivated for a strong season start; 49ers aim to rebound from recent Super Bowl loss and offseason setbacks; Seahawks seek to overcome recent ATS struggles and leverage home advantage.

Odds and Predictions

Category	Odds	Prediction	Confidence
Moneyline	San Francisco 49ers: -126, Seattle Seahawks: +108	Seattle Seahawks	★★★☆☆ 68%
Spread	San Francisco 49ers: -1.5 -110, Seattle Seahawks: +1.5 -110	Seattle Seahawks +1.5	★★★★☆ 72%
Over/under	Over 43.5: -104, Under 43.5: -118	Under 43.5	★★★☆☆ 65%

Top EV Betting Odds

Discover the best value bets based on our EV analysis.

Market	EV Pick
Moneyline	San Francisco 49ers 12%
Spread	N/A
Over/Under	Under 43.5 16%

🔥 Best Value Pick: Under 43.5 at 16% EV | Suggested Bet Size: 19.3% (Kelly Criterion)

Predicted Outcome

Seattle Seahawks take the moneyline upset due to key 49ers injuries and home advantage, covering the tight spread. Expect a game below the total points line due to offensive handicaps.

Predicted Score: Seattle Seahawks 24 – San Francisco 49ers 20