Match Analysis: San Francisco 49ers vs Arizona Cardinals – Prediction
Match Details
- Date: 2025-09-21
- Time: 8:26 PM UTC
- Location: Levi's Stadium, Santa Clara, California
Game Overview
A tightly contested NFC West divisional matchup between two undefeated teams with strong defenses and capable offenses. The 49ers enter favored at home by a narrow margin versus the Cardinals who have recent success against them in head-to-head matchups.
Key Factors to Consider
- Both teams are 2-0 with solid recent wins; 49ers show balanced offense with 344 yards last game and solid defense; Cardinals have won last two meetings convincingly and boast a strong running and passing attack.
- Cardinals have won last two meetings including a 47-24 road win; overall H2H in last 10 is balanced at 5-5.
- No major injury reports impacting key starters disclosed prior to game, both teams expected near full strength.
- Game played at Levi's Stadium benefits the 49ers' home advantage; weather not expected to be a factor.
- Both teams motivated to maintain perfect records early in season and gain divisional edge; recent psychological edge to Cardinals from last two wins.
Odds and Predictions
Category | Odds | Prediction | Confidence |
---|---|---|---|
Moneyline | home: -130, away: +110 | Arizona Cardinals | β β β ββ 67% |
Spread | home: -105, away: -115 | Arizona Cardinals +2.5 | β β β β β 72% |
Over/under | over: -108, under: -112 | Over 44.5 | β β β ββ 65% |
Top EV Betting Odds
Discover the best value bets based on our EV analysis.
Market | EV Pick |
---|---|
Moneyline | Arizona Cardinals 22% |
Spread | N/A |
Over/Under | Over 44.5 16% |
π₯ Best Value Pick: Arizona Cardinals at 22% EV | Suggested Bet Size: 19.8% (Kelly Criterion)
Predicted Outcome
Arizona Cardinals moneyline upset win given momentum and favorable head-to-head, with moderate confidence to back this undervalued line; expect moderately high scoring game.
Predicted Score: Cardinals 27 – 49ers 24